Purchase Lidocaine Anesthetic Cream

Lidocaine is a local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic, and in minor surgery.

Lidocaine, the first amino amide-type local anesthetic, was developed first by Nils Löfgren and Bengt Lundqvist in 1943 and first marketed in 1948.

Lidocaine use in anesthesia can be explained by the fact that it alters depolarization in neurons, by blocking the fast voltage gated sodium (Na+) channels in the cell membrane. With sufficient blockade, the membrane of the presynaptic neuron will not depolarize and so fail to transmit an action potential, leading to itsanesthetic effects. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations will also affect other modalities of neuron signaling.

Temporary relief of pain associated with minor burns and abrasions of the skin, e.g. sunburn, herpes zosterand labialis, pruritus, sore nipples, insect bites; anesthesia of mucous membranes, e.g. various anal conditions such as hemorrhoids and fissures; the alleviation of pain during examination and instrumentation, e.g.proctoscopy, sigmoidoscopy, cystoscopy, endotracheal intubation.

Recommendations

Follow the directions for using this medicine provided by your doctor. Use Lidocaine exactly as directed.

The dose of this medicine may be different for different patients. Use the smallest amount of Lidocaine to control your symptoms. The total maximum dose for a 24 hour period should not exceed 20 grams.

If possible, clean the affected area well, before each application of the medicine. Apply a thin layer, using only enough to cover the affected area.

If used on sore nipples, it is essential that you clean the nipple area completely before each feeding.

Be careful to avoid injury while the area is numb and you are not aware of pain. Avoid contact with eyes.

What to Know About the Product

Tell your doctor before using Lidocaine, if: you are allergic to any medicines;
you have any medical problems including severe broken or inflamed skin, burns, or open wounds at the place of application.

Lidocaine is an amide local anesthetic and used as topical analgesic, local anesthetic and antiarrhythmic that exerts its effects on nerve axon sodium channels, preventing depolarization.

The available preparation of lidocaine comes in cream, infusion, injection, jelly, lotion, ointment, solution

Specific Uses

Local and regional anesthesia by infiltration, nerve block, epidural, or spinal techniques; acute treatment of ventricular arrhythmias from myocardial infarction or cardiac manipulation

Dental: topical local anesthetic

Ophthalmic: To promote local anesthesia to ocular surface during ophthalmologic procedures

Rectal: Short-term relief of pain and itching due to anorectal disorders

Topical: Local anesthetic for oral mucous membrane; use in laser/cosmetic surgeries; minor burns, cuts, and abrasions of the skin

Oral solution (viscous): Topical anesthesia of injured oral mucous membranes and pharyngeal tissue

Patch (Lidoderm®): Relief of allodynia (painful hypersensitivity) and chronic pain in postherpetic neuralgia

Pregnancy Considerations

Animal studies with lidocaine have not revealed teratogenic effects. Lidocaine and the MEGX metabolite cross the placenta. Use is not contraindicated during labor and delivery. Topical lidocaine is used locally to promote analgesia prior to episiotomy and during repair of obstetric lacerations. Administration via the perineal route may result in greater absorption than administration by the epidural route. Adverse effects have been reported in the infant following maternal administration however, when used in appropriate doses, the risk to the fetus is low. Multiple exposures over a period of time from all routes of administration should be considered.

Lactation

Enters breast milk/use caution

Contraindications

Prophylactic reactions to lidocaine or any component of the formulation; hypersensitivity to another local anesthetic of the amide type; Adam-Stokes syndrome; severe degrees of SA, AV, or intraventricular heart block (except in patients with a functioning artificial pacemaker); premixed injection may contain corn-derived dextrose and its use is contraindicated in patients with allergy to corn-related products

Warnings/Precautions

Disease-related concerns:

• Hepatic dysfunction: Use intense caution in patients with severe hepatic dysfunction; may have increased risk of lidocaine toxicity.

• Pseudocholinesterase deficiency: Be careful with patients with pseudocholinesterase deficiency; may have increased risk of lidocaine toxicity

Dosage form specific issues:

• Injectable anesthetic: Follow acceptable administration techniques so as not to administer any intravascularly. Solutions with antimicrobial preservatives should not be used for epidural or spinal anesthesia. Some solutions include a bisulfite; avoid in patients who are allergic to bisulfite. Resuscitative equipment, medicine and oxygen should be accessible in case of emergency. Use products with epinephrine cautiously in patients with significant vascular disease, compromised blood flow, or during or following general anesthesia (increased risk of arrhythmias). Regulate the dose for the elderly, pediatric, acutely ill, and debilitated patients.

• Intravenous: Regular ECG monitoring is necessary during I.V. administration. Use carefully in hepatic impairment, any degree of heart block, Wolff-Parkinson-White syndrome, HF, marked hypoxia, severe respiratory depression, hypovolemia, history of malignant hyperthermia, or shock. Faster ventricular rate may be seen when administered to a patient with atrial fibrillation. Rectify electrolyte disturbances, especially hypokalemia or hypomagnesemia, prior to use and throughout therapy. Correct any underlying causes of ventricular arrhythmias. Monitor closely for signs and symptoms of CNS toxicity. The elderly may be at risk to increased CNS and cardiovascular side effects. Reduce dose in hepatic dysfunction and CHF.

• Ophthalmic: For ophthalmic use only; not for injection. Prolonged use may cause permanent corneal ulceration and/or opacification with loss of vision.

• Topical: Do not leave on large body areas for >2 hours. Life threatening side effects are likely to happen. (e. g. irregular heartbeat, seizures, coma, respiratory depression, death) have occurred when used prior to cosmetic procedures. Monitor young children closely to prevent accidental ingestion. Not for ophthalmic use. Some products are not advocated for use on mucous membranes; consult specific product labeling.

• Transdermal patch: Safety and efficiency have not been established in children.

Other warnings/precautions:

• CAST trial: In the Cardiac Arrhythmia Suppression Trial (CAST), recent (>6 days but <2 years ago) myocardial infarction patients with asymptomatic, non-life-threatening ventricular arrhythmias did not benefit and may have been harmed by attempts to suppress the arrhythmia with flecainide or encainide. An increased mortality or nonfatal cardiac arrest rate (7.7%) was seen in the active treatment group weighed against patients in the placebo group (3%). The applicability of the CAST results to other populations is not known. Antiarrhythmic agents should be exclusive only for patients with life-threatening ventricular arrhythmias.